This systematic review looks at what actually works to reduce workplace accidents and injuries. Drawing on a large body of international evidence, it shows that isolated safety initiatives, like one-off training or policy changes, are unlikely to be effective on their own. Instead, the strongest results come from combining multiple approaches and embedding safety into everyday working practices. The research also highlights the role of leadership, consistency, and context in determining success. Overall, it reinforces that improving workplace safety requires a structured, organisation-wide approach rather than standalone interventions.