This study explores how individual factors and workplace conditions interact to influence work ability in employees experiencing pain and stress-related ill-health. Using a network analysis approach, it finds that perceived stress and “catastrophising” (a tendency to expect or focus on worst-case outcomes) are the most influential factors, closely linked to work limitations, health, and quality of life. Work environment factors such as demand, control, and support are connected but play a less central role overall. The findings suggest that work ability is shaped by a combination of personal and workplace factors, with psychological responses playing a key role.